BOMBSHELL STUDIES

Nanomaterials Used in COVID-19 ARE the Next Asbestos!

Absolutely shocking scientific evidence

was published in 2014 proving that multi-walled carbon nanotubes - the "miracle material" of nanotechnology - cause mesothelioma cancer in test mice! ("Carcinogenic effects of various multi-walled carbon nanotubes (MWCNTs) after intraperitoneal injection in rats").

This study, published in Particle and Fibre Toxicology, followed a 2008 scientific study published in Nature Nanotechnology, which also proved that multi-walled carbon nanotubes induce asbestos-like pathogenicity in mice! ("Carbon nanotubes introduced into the abdominal cavity of mice show asbestos-like pathogenicity in a pilot study").

Before we get into these studies, it must be said that this very material has been widely used throughout "Covid" since its beginning in 2020!

The results of these two studies mean the END of using masks, tests and drug therapies based on these materials on humans!

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8577996/ Carbon nanotubes in COVID-19: A critical review and prospects

The utility of Carbon nanotubes in the prevention, diagnosis and treatment of COVID-19.

This review encompasses the various biosensor and nanobiosensors employed in the prevention, diagnosis and treatment of SARS-CoV-2 infection. The prime focus of this review is to summarize and critically review the recent advancements in Carbon nanotubes-based biosensors for a spectrum of uses amid the COVID-19 pandemic.

The utility of Carbon nanotubes in the prevention, diagnosis and treatment of COVID-19.

Carbon nanotubes are used commercially. They are widely used in the manufacturing, electronics, packaging and even food industries.

Despite evidence that multi-walled carbon nanotubes cause mesothelioma in test mice.... they have been widely used in COVID-19!

WHO APPROVED AND ALLOWED THIS TO HAPPEN?

Just to give a few examples of the use of these carbon nanotubes:

• the carbon nanotubes (CNTs) face mask filters and respirator filters (https://www.graphene-info.com/israeli-researchers-develop-graphene-based-self-sterilizing-air-filter, https://www.embs.org/pulse/articles/versatile-graphene-underlies-new-covid-zapping-air-filter/, https://medium.com/edge-of-innovation/how-safe-are-graphene-based-face-masks-b88740547e8c, https://www.azonano.com/news.aspx?newsID=38205)

• the carbon nanotubes (CNTs) personal protective equipment

• nanomaterial-based biosensors, including PCR tests (https://news.mit.edu/2021/carbon-nanotube-covid-detect-1026, https://www.azonano.com/article.aspx?ArticleID=5892, https://www.azonano.com/news.aspx?newsID=37676, https://www.nsmedicaldevices.com/news/graphene-sensor-covid-19-test/,https://www.azonano.com/article.aspx?ArticleID=5892)

• drugs and vaccines

  

• https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7993985/ Recent advances in carbon nanomaterials for biomedical applications: A review

  

  Carbon Nano Tubes are hydrophobic materials that exhibit nonuniform dispersity in biological environments; functionalization of the CNT surface can overcome this limitation. When exposed to oxidative agents, CNTs form carboxylated surfaces. The carboxylated CNT materials are uniformly dispersed and biocompatible materials that can be loaded with drugs.

LET'S TAKE A LOOK AT THIS SHOCKING 2014 STUDY:

https://particleandfibretoxicology.biomedcentral.com/articles/10.1186/s12989-014-0059-z The carcinogenic effect of various multi-walled carbon nanotubes (MWCNTs) after intraperitoneal injection in rats | Particle and Fibre Toxicology | Full Text (biomedcentral.com)

Biological effects of tailor-made multi-walled carbon nanotubes (MWCNTs) without functionalization were investigated in vivo in a two-year carcinogenicity study.

A total of 500 male Wistar rats (50 per group) were treated once by intraperitoneal injection with 109 or 5 × 109 WHO carbon nanotubes of one of four different MWCNTs suspended in artificial lung medium, which was also used as negative control.

Results

Treatments induced tumors in all dose groups, but incidences and times to tumor differed between groups. Most tumors were histologically and immunohistochemically classified as malignant mesotheliomas, revealing a predominantly superficial spread on the serosal surface of the abdominal cavity. Furthermore, most tumors showed invasion of peritoneal organs, especially the diaphragm. All tested MWCNT types caused mesotheliomas. We observed highest frequencies and earliest appearances after treatment with the rather straight MWCNT types A and B. In the MWCNT C groups, first appearances of morbid mesothelioma-bearing rats were only slightly later. Later during the two-year study, we found mesotheliomas also in rats treated with MWCNT D – the most curved type of nanotubes. Malignant mesotheliomas induced by intraperitoneal injection of different MWCNTs and of asbestos were histopathologically and immunohistochemically similar, also compared with mesotheliomas in man, suggesting similar pathogenesis.

Conclusion

We showed a carcinogenic effect for all tested MWCNTs. Besides aspect ratio, curvature seems to be an important parameter influencing the carcinogenicity of MWCNTs.

Discussions about the hazardous potential of CNTs began very early, with regard to possible toxic and carcinogenic effects well known from persistent natural and man-made mineral fibers. CNTs came under suspicion, because the generally accepted prerequisites for a mineral fiber to be able to exert a carcinogenic effect in the lung and pleura can also be found in some CNTs.

Fiber-specific tumors are mesotheliomas of the pleura, but lung tumors are caused as well.

Man-made mineral fibers (MMMF) displaying low solubility, high biopersistence, and fulfilling the WHO fiber definition caused lung tumors and mesotheliomas in experimental animals in a way very similar to asbestos fibers.

For this test, a suspension of a certain number concentration of WHO fibers of the mineral fiber under evaluation is injected once into the peritoneum of rats, and the animals thus treated have to be kept for two years and investigated histopathologically for mesotheliomas.

In the present study, we investigated only MWCNTs. SWCNTs and also MWCNTs can be very long, reaching dimensions comparable to long mineral fibers, and CNTs are almost insoluble because of their inorganic carbon structure. This means that some MWCNTs also meet the prerequisites for causing fiber-specific toxic effects.

Early pathological effects observed after short-time intraperitoneal administration of CNTs in mice were very similar to effects observed with asbestos fibers.

Experimental animals were killed when morbid or after two years of experimental time.

The tumors induced by intrapleural or intraperitoneal injection of asbestos fibers in rats were classified as malignant mesotheliomas closely resembling human malignant mesothelioma in their biological behavior and histopathology. Human malignant mesotheliomas have been described to show epithelial, sarcomatoid, or biphasic growth patterns. The same categories have been specified for rat mesotheliomas. For mesotheliomas in humans, a variety of immunohistochemical antigens have been described. Key features seem to be the occurrence of vimentin in the majority of mesotheliomas, a marker for mesenchymal cells and mesothelium, wide-spectrum cytokeratin as a marker for epithelial cells and mesothelium, and positivity for podoplanin, which is a marker for lymphatic endothelium. These markers were also observed in mesotheliomas of rats.

In the present study, the tumor material was investigated histopathologically and immunohistochemically for the three markers cytokeratin, vimentin, and podoplanin.

All MWCNTs tested in this study showed a strong carcinogenic effect. Besides the diameter and length of MWCNTs, curvature seems to have had an influence on carcinogenic potency. (!!!)

In the MWCNT A and B low- and high-dose groups and in the MWCNT C high-dose group, 80% of the animals died or were humanely killed due to a bad clinical condition. In the MWCNT C low-dose group, mortality reached 80% 16 months after the intraperitoneal treatment. The MWCNT D high-dose group showed 80% mortality after 23 months. At the end of the experimental time after 24 months, mortality was 56% in the MWCNT D low-dose group, 76% in the amosite asbestos group, and 34% in the negative control group.

A group was terminated when 80% mortality was reached.

At necropsy most animals of the MWCNT treatment groups and the majority of rats of the amosite asbestos group revealed ascites consisting of blood-containing fluid. Most animals showed adhesions and multifocal to coalescing small nodular lesions on the surface of the abdominal organs. Many rats had large nodules or tissue masses especially in the area of the diaphragm, liver, and pancreas, but the small intestine was also frequently involved. In some animals, we found aggregates of foreign material covered by a thin layer of serosa, primarily at the diaphragm and liver. The liver and spleen capsules were thickened and firm in numerous rats.

The most frequent tumors in the MWCNT and amosite asbestos treatment groups were malignant mesotheliomas of the peritoneum. In most cases these tumors were the obvious reason for a morbid condition of the rats and triggered the decision to perform euthanasia. In addition, we found a few pancreatic islet-cell adenomas, Leydig cell adenomas of the testes, and one renal lipoma.

Rats in the MWCNT A groups developed a mesothelioma rate of 98% in the high-dose group and of 90% in the low-dose group. Mesothelioma-bearing animals had a mean survival time of 194 days in the high-dose group and of 231 days in the low-dose group.

In the MWCNT B groups, we found mesothelioma rates of 90% (high dose) and 92% (low dose). Survival times of mesothelioma-bearing rats were 207 days (high dose) and 294 days (low dose).

Incidences of mesotheliomas in the MWCNT C groups were 94% after treatment with the high dose and 84% with the low dose. In these groups, mesothelioma-bearing rats had a mean survival time of 265 days with the high dose and of 415 days with the low dose.

Animals of the MWCNT D treatment groups developed malignant mesotheliomas in 70% (high dose) and 40% (low dose). Survival times of the mesothelioma-bearing rats were 585 days with the high dose and 666 days with the low dose.

In the amosite asbestos group, the mesothelioma incidence was 66%, with a mean survival time of 623 days.

In the rats of the medium control group, we found one mesothelioma (2%) during final necropsies.

Other non-neoplastic MWCNT-induced histopathological findings in the abdominal cavity

Most of the MWCNT-treated rats showed multiple granulomas on the peritoneal surface of the abdominal organs and diaphragm. The granulomas frequently consisted of a central hyaline area which mostly included a few single fibers, surrounded by macrophages and lymphocytes. An outer layer of fibrocytes and collagen, covered by serosa, was mostly visible. Organs such as the liver and spleen were engulfed by a thick layer of collagen-rich connective tissue intermingled with granulomas. In many cases, the liver showed adhesions to the diaphragm by fibrotic if not tumor tissue. We found agglomerates of foreign material underneath the serosa in many animals. Multifocal papillary projections of mesothelial hyperplasia were observed especially on the diaphragm and diaphragmatic liver surface.

Histologic appearance of malignant mesotheliomas

Malignant mesotheliomas showed predominantly superficial growth on the serosal surface of the peritoneum of the liver, spleen, intestine, and abdominal wall. We frequently observed invasion into the mesentery, pancreatic tissue, and diaphragm. All in all, 320 of the 329 MWCNT-related malignant mesotheliomas had invaded the diaphragm, and 174 of these tumors showed invasion of the thoracic cavity. In the amosite asbestos group, which displayed 33 (66%) mesotheliomas, 29 mesotheliomas had invaded the diaphragm, and 5 of these tumors showed invasion of the thoracic cavity.

In the majority of cases, the liver was completely encapsulated, but it was frequently invaded as well. In contrast, invasion of the spleen along the vascular blood supply was rare. All malignant mesotheliomas showed some cellular pleomorphism; some of the tumors exhibited partly anaplastic round cells, especially those occurring early in the study. A couple of mesotheliomas developed areas with mucus production, others showed microcystic areas.

The most frequent type of mesothelioma was the sarcomatoid type, followed by mesotheliomas of the biphasic type. Mesotheliomas of the epithelioid type were rare.

Tumor incidences in all MWCNT dose groups treated with 109 or 5 × 109 nanotubes were 40 to 100%. Our experimental results thus clearly provide proof of the mesothelioma-inducing potential of these MWCNTs in rats.

The carcinogenic effect of the tested nanotubes might be due to frustrated phagocytosis followed by chronic inflammation, which has been described for asbestos fibers and for MWCNTs as well.

Poorly soluble but otherwise non-toxic particles that are non-digestible and non-degradable can harm macrophages when they take up a large volume of this material or when this material activates and damages the macrophages due to its long fiber shape. These macrophages will no longer be able to move properly and eliminate the foreign material.

Activated and apoptotic macrophages and interaction of the foreign material with surrounding epithelial cells then causes an inflammation that becomes chronic because of the continuing irritant and damaging effect of the foreign material. This particle-induced chronic inflammation and the high concentration of reactive oxygen and nitrogen species generated in the course of the inflammatory process can also lead to oxidative damage and genotoxic effects.

Spontaneous mesotheliomas in rats occur at a low incidence. In aged Wistar rats, incidences are up to 4% in males and 0% in females.

In our medium control group, we found one mesothelioma (2%). Consequently, the mesotheliomas we found in the MWCNT groups of our study at incidences ranging from 40 to 98% must be regarded almost completely as induced by the tested MWCNTs.

There is thus a very high probability that a variety of multi-walled carbon nanotubes are also potent carcinogens like asbestos for humans. Our test was designed for hazard identification of MWCNTs, not for risk assessment. We were able to show that the selected carbon nanotubes had mechanistic potency to induce tumors, comparable to that of asbestos fibers. Inhalation exposure to lower doses of these carbon nanotubes should be performed in the future to enable proper risk assessment. The diameter, length, and shape of the carbon nanotubes seem to be essential parameters determining their carcinogenic potential.

All man-made mineral fibers longer than 5 μm and thinner than 3 μm and having a length-to-diameter ratio of at least 3:1 have to be treated as potential human carcinogens, if their half-time in rat lung is similar to the half-time of mineral fibers known to induce tumors in humans or rats after inhalation exposure.

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http://www.n3cat.upc.edu/papers/carbon%20nanotubes%20and%20cancer.pdf Carbon nanotubes introduced into the abdominal cavity of mice show asbestos-like pathogenicity in a pilot study.

This study leads to the same conclusion regarding the carcinogenic properties of carbon nanotubes.

Despite overwhelming evidence that multi-walled carbon nanotubes cause mesothelioma in the mice tested, the technology has apparently been unleashed on humans.

People MUST NOT inhale these toxic graphene-based materials, have them inserted (as a "PCR test") or be injected with this extremely toxic nanotechnology.

The increase in cancer, among other adverse effects, is due to the use of this technology, as these studies prove, and this must be stopped immediately.

The nanotechnology used is a causal link to these innumerable observed side effects and deaths.