I V E R M E C T I N

why it works

So, I just read Meryl Nass Substack post:

https://merylnass.substack.com/p/if-there-was-still-any-question-about

and I had to comment on it. Here is my comment on the subject, that I am happy to share with you:

MY very simple, yet brilliant explanation of WHY IVERMECTIN (great safety profile!) WORKS - FREE EXPLANATION FOR AMA IDIOTS - from me:

1. zinc stops virus replication and prevents oxidative stress.

But. Zinc is water-soluble, not fat-soluble. It needs an ionophore to enter the cell.

2. ivermectin is a zinc ionophore.

3. so Ivermectin transports zinc into the cell and zinc acts against the virus, stops oxidative stress and cell apoptosis (cell death).

TRUST THE SCIENCE: IVERMECTIN

So, let's look into SCIENCE:

https://www.prnewswire.com/news-releases/studies-show-zinc-inhibits-viral-replication-but-theres-a-catch-301079772.html

"One major function of zinc to human is its ability to boost the body's immunity and fight viruses. Studies show that zinc can block the replication and growth of viruses in the body and in lab tests. In the body, zinc improves the actions of immune cells like Neutrophils, T cells, B cells and NK that act as the police of the body, which attack infections.

Zinc is found and operates in every cell of the body, but it's a non-fat-soluble mineral that can't move through the fat-based cell membrane. Therefore, it needs help to cross the cell membrane from special transport systems. These systems include zinc ionophore and zinc binding-proteins. The zinc binding-proteins are located in all membranes of every cell of the body for efficient inflow and outflow of zinc in the cells.

Ionophore is a fat-soluble substance that can transport non-fat soluble elements across the cell membrane. Zinc-ionophores are zinc transporters in and out of the cell and can increase the effects of zinc in the cell. For example, Hinokitiol, a natural substance found in the Cupressaceae trees is a potent zinc-ionophore. It's known for its antimicrobial, antiviral and anticancer properties and it's regarded as the safest zinc-ionophores compared to other ionophores like hydroxychloroquine, quercetin, epigallocatechin, pyrithione, zincophorin, etc. Hinokitiol doesn't accumulate in the body and it has no recorded drug allergy or unfavorable effects, unlike hydroxychloroquine.

Conclusion:

Zinc has a vital role in human health. Several studies showed that Zinc and Hinokitiol can repress viruses in the body, and in the lab. Consequently, Zinc and Hinokitiol supplements are useful in treating viral infections.

https://pubmed.ncbi.nlm.nih.gov/31305906/ "Consequently, zinc status is a critical factor that can influence antiviral immunity, particularly as zinc-deficient populations are often most at risk of acquiring viral infections such as HIV or hepatitis C virus. This review summarizes current basic science and clinical evidence examining zinc as a direct antiviral, as well as a stimulant of antiviral immunity. An abundance of evidence has accumulated over the past 50 y to demonstrate the antiviral activity of zinc against a variety of viruses, and via numerous mechanisms. The therapeutic use of zinc for viral infections such as herpes simplex virus and the common cold has stemmed from these findings; however, there remains much to be learned regarding the antiviral mechanisms and clinical benefit of zinc supplementation as a preventative and therapeutic treatment for viral infections."

Coronavirus Inhibition of RdRp template binding and elongation PT + Zn(OAc)2 2–320 μM PT + 2–500 μM Zn - te Velthuis AJ, van den Worm SH, Sims AC, Baric RS, Snijder EJ, van Hemert MJ. Zn(2+) inhibits coronavirus and arterivirus RNA polymerase activity in vitro and zinc ionophores block the replication of these viruses in cell culture. PLoS Pathog. 2010;6(11):e1001176.

"Other respiratory tract infections: influenza, coronavirus, and metapneumovirus

Few studies have examined the antiviral effects of zinc on other respiratory viruses. In vitro replication of influenza (PR/8/34) is significantly inhibited by the addition of the zinc ionophore pyrrolidine dithiocarbamate (110), perhaps through inhibition of the RNA-dependent RNA polymerase (RdRp), as had been suggested 30 y earlier (111). In similar fashion, severe acute respiratory syndrome (SARS) coronavirus RdRp template binding and elongation was inhibited by zinc in Vero-E6 cells (60). Moreover, zinc salts were shown to inhibit respiratory syncytial virus, even while zinc was incubated with HEp-2 cells only before infection, and then removed (72). The authors suggest that this indicates an inhibitory mechanism similar to HSV by preventing viral membrane fusion; however, no measures were taken to assess changes in intracellular zinc content, nor inhibition of other aspects of the viral life cycle.

In summary, it is evident that zinc possesses antiviral properties against a number of viral species. Although mechanistic studies are lacking, zinc appears to inhibit viral protease and polymerase enzymatic processes, as well as physical processes such as virus attachment, infection, and uncoating (Figure 1). Unfortunately, these mechanisms have not been well scrutinized in clinical studies, where zinc may provide inexpensive and effective adjunct treatments for many viral infections.

Conclusions and Future Perspectives

The tight regulation of zinc homeostasis both systemically and intracellularly indicates that zinc plays an essential role in human health. Although zinc is a component of ∼10% of the human proteome, zinc in different forms (free compared with protein-bound) can stimulate a variety of signaling events, including the antiviral response. In vitro studies suggest that free zinc may possess potent antiviral effects, and are supported by trials of creams, lozenges, and supplements with high free zinc content. Moreover, zinc-binding proteins such as the metallothioneins may possess antiviral roles, although their specific function remains uncertain. Nonetheless, zinc treatment applied at a therapeutic dose and in the right form has the potential to drastically improve the clearance of both chronic and acute viral infections, as well as their accompanying pathologies and symptoms. Consequently, the role of zinc as an antiviral can be separated into 2 categories: 1) zinc supplementation implemented to improve the antiviral response and systemic immunity in patients with zinc deficiency, and 2) zinc treatment performed to specifically inhibit viral replication or infection-related symptoms "

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5835698/pdf/ajcr0008-0317.pdf " Ivermectin acts as an ionophore and up-regulates chloride channels to generate apoptosis and osmotic cell death"

Ivermectin as an ionophore drug The term ‘ionophore’ was first used in 1967 in reference of the ability of organic molecules to bind metal cations and to form lipid soluble complexes that facilitate their transport across cellular membranes. Thus, ionophores can diffuse back and forth between the extracellular and intracellular spaces, or may remain in the plasma membrane as their transport metal ions between intracellular and extracellular spaces [42]. Ionophore antibiotics act by generating pores in biological membranes that dramatically alter the ionic household of cells. Salinomycin is an example of an ionophore antibiotic which generates ion channel-like structures that exhibit strong selectivity for K+ , but other monovalent cations are also conducted (e.g., Na+ and H+ ) [43]. Traditionally, the cell killing activity of ionophore antibiotics is thought to originate from profoundly deregulating osmosis, as well as from direct cytotoxic effects of the altered biochemical landscape. It is known that malignant cells tend to upregulated chloride channels, which potentially could mark them as more sensitive to alterations in chloride flux, and that an unbalance in intracellular chloride concentrations affects intracellular Ca2+ levels, as well as pH and cell volume, which can lead to apoptosis in the affected cell.

Pressman BC. Biological applications of ionophores. Annu Rev Biochem 1976; 45: 501-30.

Mitani M, Yamanishi T and Miyazaki Y. Salinomycin: a new monovalent cation ionophore.

Biochem Biophys Res Commun 1975; 66:

1231-6.

Where did all these idiots graduate from????

They contradict themselves. This is unbelievable.

In fact, in my opinion, more important than zinc's antiviral property is its antioxidant property.

THIS IS THE CORE OF THE PROBLEM: OXIDATIVE STRESS