https://medalerts.org/vaersdb/findfield.php?TABLE=ON&GROUP1=SYM&EVENTS=ON&VAX=COVID19 Search Results from the VAERS Database (medalerts.org)Thanks for reading OUTRAGED’s Newsletter!
As an ob/ gyn , I agree with your discussion, asked a few colleagues about the concept and they all agree but there is perhaps more to add to the story regarding estrogen receptors and blocking the anterior pituitary to the ovary . Thank u for this essay and the deep dive .
"One of the most experienced free-radical researchers, the Japanese biochemist Yukie Niwa, estimates that at least 85% of chronic and degenerative diseases result from oxidative damage."
Therefore, cancer may develop only in those organs that synthesize hydroxyl metabolites of estrogen at the target site of carcinogenesis, which may elicit biological activities distinct from βE2; most notably, an oxidant stress response induced by free radicals generated by metabolic redox cycling reactions. In summary, our data support the concept that oxidative stress plays a critical role in estrogen-induced carcinogenesis.
Ample evidence exists to suggest that (i) estrogens play a role in breast cancer initiation and progression and (ii) that one of the mechanisms includes an oxidative stress-mediated pathway.
Current evidence indicates that estrogens attenuate oxidative stress at two levels: first, by preventing generation of reactive oxygen species (ROS) and, second, by scavenging ROS in the myocardium and in the vasculature. The purpose of this review is to give an overview on current concepts on conditions and mechanisms by which estrogens protect the cardiovascular system against ROS-mediated cellular injury.
Reading an article like this all of a sudden I am concerned. Then I read about the food and laugh, I eat plenty of healthy food, am already feeling good, concerned over words only.
As an ob/ gyn , I agree with your discussion, asked a few colleagues about the concept and they all agree but there is perhaps more to add to the story regarding estrogen receptors and blocking the anterior pituitary to the ovary . Thank u for this essay and the deep dive .
"One of the most experienced free-radical researchers, the Japanese biochemist Yukie Niwa, estimates that at least 85% of chronic and degenerative diseases result from oxidative damage."
Would like to know his supplement regimen 🌻
Maybe useful for you:
https://www.pnas.org/doi/10.1073/pnas.0437929100
Therefore, cancer may develop only in those organs that synthesize hydroxyl metabolites of estrogen at the target site of carcinogenesis, which may elicit biological activities distinct from βE2; most notably, an oxidant stress response induced by free radicals generated by metabolic redox cycling reactions. In summary, our data support the concept that oxidative stress plays a critical role in estrogen-induced carcinogenesis.
https://academic.oup.com/carcin/article/25/1/3/2390568
Ample evidence exists to suggest that (i) estrogens play a role in breast cancer initiation and progression and (ii) that one of the mechanisms includes an oxidative stress-mediated pathway.
https://link.springer.com/article/10.1007/s00424-013-1247-7
Current evidence indicates that estrogens attenuate oxidative stress at two levels: first, by preventing generation of reactive oxygen species (ROS) and, second, by scavenging ROS in the myocardium and in the vasculature. The purpose of this review is to give an overview on current concepts on conditions and mechanisms by which estrogens protect the cardiovascular system against ROS-mediated cellular injury.
https://www.researchgate.net/publication/334275802_The_Effect_of_Gallic_Acid_on_Pituitary-Ovary_Axis_and_Oxidative_Stress_in_Rat_Model_of_Polycystic_Ovary_Syndrome
https://ovarianresearch.biomedcentral.com/articles/10.1186/s13048-022-01032-x
https://www.frontiersin.org/articles/10.3389/fphar.2021.565748/full
Thank u , I believe too it’s described in the anti aging literature as well . I appreciate the links . Interesting connection with endometriosis.
https://www.livestrong.com/article/531520-food-sources-of-n-acetyl-cysteine/
https://www.livestrong.com/article/335859-food-sources-of-glutathione/
Reading an article like this all of a sudden I am concerned. Then I read about the food and laugh, I eat plenty of healthy food, am already feeling good, concerned over words only.