Ido Bachelet and his team have made a new type of brain-machine interface enabling a human operator to control nanometer-size robots inside a living animal by brain activity.
What an amazing (alarming) compilation of scientific articles! This is a whole new genre of concern…just when I thought the globalists had met quota >__<
And nanotechnology is all about genociding humanity... framed in the premise of medical advancements. NOT! Remember... they want 7 BILLION People dead by 2030. The deadly medical industry is full of s..t!!! Don't believe a word they say.
OMG!!!!! Who can even read this....pleeeeeeeezzzzeee...let me just be a human. Remember, that old thing that just had the 23 pairs of chromosomes...that highly flawed, yet mischievously ingenious old earth creature...I want myself back....pppllllleeeeeeezzzeee....gasp....gasp....
First, we cannot see anything smaller than fits in the optical microscope. All technologies with higher “resolution” are either snapshots of a very minuscule something or complete fiction based on “images” of dead something (following a protocol on how to prepare samples for electron microscopy) - again random and very minuscule.
The field of vision of these “images” is ridiculous. And it is not continuous: you cannot scroll the image left, right up or down. Most importantly, you cannot “see” the sample in its depth - because it has no depth, it is an ultra thin slice of dead something. It is dead - we cannot observe nano-scale things live.
None of these technologies are replicable. None of them leaves the “sample” intact for another observation. Since we cannot see what is happening there, the resulting “images” are pure fantasy ornamented with elaborate descriptions. None of these technologies can offer continuous observation of one particular sample over time long enough to draw any conclusions - cross-referenced to other observations of the same sample at a different point in time (like two days later).
Therefore, DNA, strands, or whatever they call it that is below the threshold of true observation (continuous, at different time points, under different stimuli, within large field of vision) is only inference at best and pure fantasy in general.
Second, how do you “control” structuring of something which you cannot see? How do you ensure that ALL presumed components fit nicely into a pattern of your imagination? What if some alleged “staples” go rogue and hide within the “good” structure? You won’t be able to detect it - because the sample intended for the detection / verification process would have to be destroyed.
Therefore, whatever is “produced” is completely unknown and unknowable. We do not have technical means to make true images of it, in all its sections and dimensions. We are unable to make a true inventory of a particular sample. And we cannot compare samples and check whether their contents (inventory) is identical or not across the whole “lot”.
Third, even if we had such technologies, how would you ensure 100% (with like million decimal places) repeatability of the “manufacturing” process when the material used is supposedly “live” (biological)?
Please. Give a link to a peer-reviewed paper that describes a true study of a live matter in any ultra-high res over an extended period of time, re-using the same sample, and resulting in real-time continuous movie of how the affected samples change. A “proof of life” of the said samples would be nice. One link will do, although - since science is based on replication of processes - more are needed to make it believable.
DNA have been used for the rational design and construction of nanoscale Objects for nearly 30 years. Recently, ‘scaffolded DNA origami’ has emerged as one of the most promising assembly techniques in DNA nanotechnology with a broad range of applications (Rothemund, 2006, Nature, 440, 297-301). Since the creation of this method, software was developed to assist the process using computer-aided design (CAD) software allowing pre-calculating and determining the sequences of scaffolds and staples needed to form a certain shape.
Despite the big promise, DNA origami did not penetrate strongly to the industry. One of the main obstacles is the high price of the raw material, i.e., the single stranded DNA. While only small quantities are needed for regular laboratory experiments, when commercialization is considered, the cost is too high.
Although it is a well-known fact that RNA is much more abundant than DNA, RNA was not considered a potential “raw material” for production of origami structures. Endo et al., (Chem. Eur. J. 2014, 20, 15330-15333) and Wang et al., (Chem. Commun., 2013, 49, 5462-5464) describe preparation of nucleic acid origami using relatively short strands of artificially transcribed RNA with limited yield. Gerasimova and Kolpashchikov (Angew. Chem. Int. Ed. Engl. 2013 52(40) doi:10.1002anie.201303919 described an assay that analyzes bacterial RNA exploiting deoxyribozyme sensors—two DNA stands containing fragments complementary to a target analyte and fragments complementary to a fluorophore and quiencher-labeled fluorogenic reporter substrate. Gerasimova and Kolpashchikov showed that hybridization of the staples to the RNA unwinds its secondary structure to form “deoxyribozymes-on-a-string” complex. However, there is no example for real tools allowing mass-production of cheap and readily available origami nanostructures. There is an unmet need for methods utilizing a cheap source of genetic material that may be used for industrial scale manufacture of biological nanostructures.
SUMMARY OF THE INVENTION
Approximately 80 percent of the total RNA in rapidly growing mammalian cells (e.g., cultured HeLa cells) is a ribosomal RNA (rRNA) making it one of the most available and cheapest sources of genetic material. Until now, rRNA was not considered as a potential material for developing rationally designed biological structures. The present invention shows for the first time that rRNA may be used for manufacturing 2D and 3D rRNA origami nanostructures. Methods for processing rRNA and its folding to rRNA origami structures are provided as well.
In one aspect, the present invention provides an RNA origami nanostructure comprising one or more scaffold nucleic acid strands and a plurality of staple nucleic acid strands, wherein said one or more scaffold nucleic acid strand(s) comprises a ribosomal RNA (rRNA) nucleic acid strand, fragment or analog thereof.
Since its introduction several years ago (Rothemund, 2006), scaffolded DNA origami has emerged as a powerful and elegant approach for bottom-up fabrication of complex shapes at the nanoscale. Shih, Douglas and others have extended DNA origami from 2D to 3D, and enhanced it with an open-source computer-aided design (CAD) tool, caDNAno (Dietz et al., 2009; Douglas et al., 2009a; Douglas et al., 2009b), enabling a remarkably diverse array of shapes that have been used for various applications, including imaging (Jungmann et al., 2012; Jungmann et al., 2010; Steinhauer et al., 2009), potential therapeutics (Douglas et al., 2012; Schuller et al., 2011), and metamaterials (Kuzyk et al., 2012; Bell et al., 2012; Schreibe et al., 2011).
WO 2012/061719 and Douglas et al. (2012), herein incorporated by reference as if fully described herein, disclose a DNA origami device useful in the targeted delivery of biologically active entities to specific cell populations.
In this invention, we describe an improved nucleic acid origami platform providing functional, stable, safe, non-immunogenic, and remote controllable therapeutic nano-devices. The platform also provide the means to provide a cargo in a ligand concentration dependent manner, control the activity of the devices by closing them at predetermined conditions, separately control multiple types of cargo, extend the shelf life of molecules such as drugs, vaccines, proteins, growth factors, cytokines, RNA molecules etc., and a tunable system to prevent drug tachyphylaxis by suppressing the endocytosis of drug-bound receptors from the cell surface. The platform is based on methods for modifying DNA origami devices by the addition of small molecule chemicals, peptides or large proteins, additional nucleic acid molecules,
inorganic quantum dots, nanocrystals or nanoparticles, liposomes, polysaccharides, polymers, carbon nanotubes, and additional materials.
The methods can also include enzymatic or non-enzymatic modification of the composition and structure of the DNA from which the device is made, such as methylation, acetylation, hydroxylation, fixation by chemical means, coating, etc. Finally, the platform can be achieved by designing the DNA origami device to be made of DNA that does not include certain motifs such as CpG, AT-rich regions etc.
Etc.
There is a rich scientific literature on the subject, which you can easily find
there is no way to get rid of these nanobots? is it possible that freemasonry and transhumanists do not have an antidote to use?
Or maybe they too are full of these nanobots, but they do not have the negative effects because those electromagnetic signals with deadly instructions are not sent to them?
The toxicity of graphene and other potentially toxic components used, such as heavy metals, is key to establishing a causal link to the adverse effects it can cause.
The mere presence of toxic graphene, and similar components, can cause amyloidosis.
So, the presence of toxic graphene can cause amyloidosis. However, the technology used in these injections is also based on peptides (as has been widely reported in the scientific literature: Self-assembling peptide semiconductors | https://www.science.org/doi/10.1126/science.aam9756), the production of amyloid in the bone marrow can lead to severe amyloidosis and related complications and death, including the currently manifested so-called sudden death syndrome.
“Myeloperoxidase is the first and so far only human enzyme known to break down carbon nanotubes, allaying a concern among clinicians that using nanotubes for targeted delivery of medicines would lead to an unhealthy buildup of nanotubes in tissues.”
“It can be postulated that NAC might have reversed the effect of intraneuronal beta amyloid protein by acting on some downstream compensatory mechanisms which needs to be explored.”
https://nationaladdictionnews.com/2021/04/04/study-shows-how-the-nutritional-supplement-nac-can-help-prevent-strokes/ “The study by CHOP researchers suggests NAC may block the precipitation of amyloid plaque deposits, as well as help break up their formation, which could make a dramatic difference for those living with HCCAA.” “Amyloids cannot precipitate without aggregating, so if we can prevent that aggregation with a drug [NAC] that is already available, then we could make an incredible difference in the lives of these patients.”
"One of the most experienced free-radical researchers, the Japanese biochemist Yukie Niwa, estimates that at least 85% of chronic and degenerative diseases result from oxidative damage."
And yes, that's EXACTLY my conclusion!
Thus,
NAC, MSM (organic Sulphur), glycine are precursors of glutathione and does not allow aggregation of amyloid plaque formations (and they dissolve amyloid plaque formations)
They also prevent oxidative stress/oxidative damage
One more thing - high temperature, UV light, blood acidity (opposite to alkaline), EMF are the elements that increase the formation of amyloid plaques. Therefore, first one needs to dissolve the amyloids, using NAC, etc., only then one can go to the sauna, stay in the sun, exercise intensively, etc.
Various cleansing methods, such as juicing, enemas, infra-red sauna, alkaline diet, etc. will be helpful, but the most important thing to start with is to dissolve these amyloid structures. Later, it is necessary through supplementation to maintain the right balance of oxidative stress to prevent oxidative damage (leading to blood clotting, amyloidosis, organ damage, death, etc.).
This will take time, as the biodistribution of this nanotechnology is into various organs, including bone marrow
I already have some nac sachets at home, 600mg each.
On substack I also follow "managainstthemicrobes" and Dr. Ana Mihalcea. It seems that this amyloidosis also comes from a continuous accumulation of darpa hydrogel and polymers. For this reason, the intake of sodium citrate and methylene blue is suggested.
We'll see, thank you very much for your precious help. During covid I participated in numerous protests, I also individually took a megaphone that I had at home and went to the square to warn people of the risks of the covid vaccine, but very few people understood me. Then I received so many threats and I had to stop, I was afraid.
And this is a very dangerous condition. If I were you, I would immediately take 2-3000 mg of NAC daily, plus other antioxidants. You can monitor it with a d-dimer test, as I wrote;
In many pharmacies around the world, you can also buy ACC, the active ingredient of which is N-acetylcysteine (600mg), then I would take about 4 tablets a day (sometimes there is no time for online shipping)
one last thing: do you think that chlorella is another valid ally? in this link it seems that graphene oxide incorporates chlorella, but it is not clear if chlorella is then expelled from the body (with the go) or not, so I do not understand its effectiveness as a chelator. You can take a look and let me know, obviously when you have time?
amyloidosis would also explain why they find all those filaments that look like rubber inside the blood vessels of cadavers, but in reality they would be assembled proteins. They worked on multiple fronts at the same time, to destroy all of Humanity.
How much NAC do you think we should take? hoping to find a product that is not contaminated....
I tried CDS, that is, chlorine dioxide, but I had strange symptoms, that is, I was worse, my eyes were full of broken capillaries and very red, and sporadic chest pains. I stopped taking CDS, and I read everywhere that the latter reduces graphene oxide into reduced graphene oxide (rGO) which is even more inflammatory, and even more dangerous. Furthermore, if the situation presents a widespread and massive hyper inflammation, why use a product that oxidizes the tissues?
On the other hand, NAC being a precursor of glutathione, and therefore being an antioxidant, I would see it well as a possible ally (although there are unfortunately studies on the web that almost everything acts as a reducing agent for graphene oxide, be it melatonin, nac, vitamin c and more)
And yes, these rubbery structures are indeed amyloidosis, which is why products like NAC, cayenne pepper, etc. dissolve amyloidosis and prevent it from aggregating. Therefore, this is the key
Therefore, one of the tests that shows something is the d-dimer test
"Activation of fibrinolysis may lead to D‐dimer elevation, as the fibrinolytic pathway is known to be active in AL amyloidosis and could be the mechanism by which many patients have an increased bleeding risk."
Honestly, I have seen a huge number of people who improved after N-acetylcysteine and other antioxidants (MSM, glycine, quercetin and vit. C and zinc, resveratrol, Q10, etc.).
The clinical significance of this HIV-associated GSH deficiency is reflected by the strong association demonstrated recently between decreased survival in HIV disease and both low thiol levels in serum [42] and low GSB levels in CD4 T cells [46]. Clinical methods for replenishing GSH are well established [47]. N-acetylcysteine (NAC), a prodrug that supplies bioavailable cysteine necessary for the replenishment, is routinely administered to overcome pharmacologically induced GSH deficiency [5,6,48—51], for example due to acetaminophen or cyclophosphamide overdose. Thus, Droge [12,32,52], ourselves [45,53] and other studies [54—56] have suggested that NAC be evaluated as an effective means for preventing or reversing the GSH deficiency in HIV infection.
Drug dosage
NAC and placebo were supplied as indistinguishable effervescent tablets to be dissolved in water, juice or soda before ingestion.
Subjects were given 10 tablets (8000 mg of NAC) per day in distributed doses day.
NAC treatment is safe for HIV-infected subjects
We found no evidence of toxicity associated with NAC administration, either during the 8-week placebo controlled trial segment or the 6-month open-label segment.
NAC administration and survival
In previous studies, we have shown that low GSB levels are associated with decreased survival in an overall study group that included subjects from this trial.
Consistent with these findings, we find a significant association between NAC ingestion and improved 2—3 years survival in a Cox Proportional Hazards analysis comparing the survival (adjusted for baseline CD4 T-cell count and b2-microglobulin) of trial subjects who took NAC during the placebo-controlled and/or the open label segment of the trial with those who never took NAC.
Since NAC effectively replenishes GSH in HIV-infected people, it may also prove to be a useful therapeutic adjunct for replenishing GSH in other clinical situations.
GSH deficiency induced by alcohol and certain drugs
is well-known.
In addition, recent studies have implicated GSH deficiency in acute respiratory distress syndrome (ARDS) and septic shock [31,87—89], hepatitis [29], liver cirrhosis [18,90], hepatorenal failure [31], preeclampsia of pregnancy [91], cardiac failure [92], rheumatoid arthritis [93], neurodegenerative disorders [25,94], aging [27,95], pancreatitis [96], age-related macular degeneration [97] and diabetes [98,99].
Exploration of NAC therapy has already begun in some of these diseases [31].
I just read online that to form glutathione you need 3 amino acids: cysteine, glycine and glutamine. With only NAC, if the other two are missing, you only have a mucolytic.
I will take the other two as suggested, that is from hydrolyzed collagen peptides that are rich in glycine and glutamic acid which is then transformed into glutamine.
If you’re still just talking about the fourth industrial revolution, you can stop theorising, because it’s here and making an impact that matters on business and society.
With the digital transformation of manufacturing well underway, the only thing needed to launch the next industrial revolution is wider access to exponential technologies — robotics, artificial intelligence (AI), sensors, 3D printing, nanotechnology, quantum computing. And now that these technologies are more affordable and their size more manageable, the fourth industrial revolution is up and running.
The World Economic Forum’s Annual Meeting at Davos this year is focused on this industrial revolution for good reason. Consider these statistics. The 4.9 billion items connected via the Internet of Things (IoT) in 2015 will reach 25 billion by 2020. Advanced manufacturing technologies are expected to double in value to $85 billion-plus globally by 2019. Venture capital investment in robotics and artificial intelligence (AI) has grown more than 70 percent per year since 2011.
But to the naked eye, it may be hard to discern this revolution.
https://www.weforum.org/stories/2012/05/small-is-beautiful-materials-by-design/ Ten years ago this all sounded like science fiction. But governments have since invested nearly US$ 70 billion in nanotechnology research, eager to be at the forefront of this revolution. This will be like the shift from horses to the internal combustion engine, or from vacuum tubes to silicon chips; a transformation enabling new industries to flourish.
Patents and literature don’t count, it’s all paper. Patents do not describe anything real.
I would like to see real-time continuous recording of the actual observation of nano-scale things. Most of all, how they change (combine, move, whatever) when manipulated by “us”.
Most most of all, how “we” know that they do what they are told to and when. Do they text us? Radio comms?
If that funny layered structure is made of, say, a trillion nano-units, how do we tell #xyz to do something while - at the same time - none of its brothers react to our command?
What about inertia? Time delay between the stimulus and reaction, in between their movements, and time delay from the stop command to the actual stop.
What about noise that can mess up communication (presuming there is some effective and accurate one)? Even the electromagnetic field of the body at this scale of miniaturization must be huge. What about interference between these tiny things? The domino effect when one fails to follow the command? Will its buddies throw it outside of the structure? How? Or will they allow its dead presence to slow down or distort the working of the whole structure?
What if 10% of these things go rogue? Will we ever know it? They do not have any transmitters. We cannot watch them in real time. Even if we managed to really “build” these structures, how do we track them and make real-time surveillance? 24/7, every tiny nanosecond - because this is the timeframe at which they operate.
How would you record all these data? Where? Could these data be meaningfully analyzed and interpreted at all? The moment you pull the record out to a printer, any nano-scale structure will already be miles away from its reporting point.
How many people would be needed to track all these data? It’s beyond our capacity. Add the human “I know better” attitude, and we are all in for a huge drama in the nano-lab.
How are these things protected from strong interferences? Induction fields? Solar radiation and its volatility? These two most obvious can affect our whole grid systems - so their impact on nano-helpless items must be catastrophic.
Aside from all these aspects... Where can we find true sequences of real-time images (like 24 fps) of these nano structures living and reacting? For one continuous minute, for the starters. To be serious, these images should have the size larger than the nano structure itself - so that we could see it in its environment.
If this imagery is not available - these scientists live in a fantasy world. They will surely produce more papers and patents to cover it up. Which does not make the absence of PROOF go away.
I am not saying these things do not exist - just asking for observable PROOF, not theories, not stories “about”.
Of course, talking about how this is to be used for drug delivery, so-called precision medicine is nonsense, and I've already written about it (less than 1% of the drug goes where it was supposed to go). On the other hand, it can certainly be used as a weapon, for biometrics, for geolocation and for CBDC (cryptography).
There's so much of it. They've really spent billions on this research. There are scientific papers, books, videos, labs, technologies. I mean, my Substack has so many links, and it's just a little drop from the ocean. 5G technology for IoT (Internet of Things), IoB (Bodies), and the Internet of Everything. New UV streetlamps, photonic equipment, biometric cameras, etc. Everything is connected and dedicated to these technologies. Yet how many patents and research are hidden, in the possession of the military, etc.?
Life Sciences. The life sciences industry was one of the early areas of adoption of QD technology, especially for QDs used in fluorescent markers in diagnostic applications. This includes both the in vitro use of QDs for marking (illuminating) particular cell types or metabolic processes for understanding diseases, and in vivo imaging made possible by QD fluorescence in near infrared that can be detected in deep tissues. The fluorescent qualities of QDs provide an attractive alternative to traditional organic dyes in bio-imaging. It is estimated that QDs are 20 times brighter and 100 times more stable than standard fluorescent indicators. QD technology is also being used in place of colloidal gold nanoparticles in lateral flow test kits such as those used in the rapid Covid 19 antigen test. QDs have been reported in literature to exponential improve the sensitivity of these test enabling earlier detection.
The Federal Drug Administration (“FDA”) has issued emergency use authorization (“EUA”) for medical tests that diagnose Covid-19. The FDA is responsible for protecting the public health by ensuring safety, efficacy, and security of all human and veterinary drugs, biological products, and medical devices. With regards to medical tests, the FDA usually does this by making manufacturers meet rigorous guidelines in an approval process that can take many months. During an emergency, such as a pandemic, it may not be possible to have all the evidence that the FDA would usually have before approving a medical test. If there’s evidence that strongly suggests that patients have benefited from a test, the agency can issue an EUA to make it available. One of the minimum requirements for granting EUA is that the known and potential benefits of the test outweigh the known potential risks. However, this is a minimum requirement and not the standard. The minimum standard can be met and EUA is still not given; there may be additional requirements, such as the test meeting reasonable thresholds for safety and effectiveness and/or people in urgent need of care based on a diagnosis. EUAs are only given during a declared emergency; outside of this, an EUA is never given.
Once the pandemic is over and should FDA EUA of Covid-19 tests be revoked. The 510K approval process which requires validation and submission of the test for FDA 510(k) clearance, which is one of the normally used medical device regulatory pathways for FDA approval would be required to continue to sell the test kits in the USA.
Quantum computers can track this data. This is certainly what CERN is all about. In the end, it is harmful. It will kill and maim, under the pretext of a new “quantum financial system” and “pandemics” or other health concerns.
I appreciate your extensive replies. It will take me some time to go through it all. I respect your work here a lot. In a sense, this all is like opening another frontier for science, and, obviously, it will require a major change in the way how we perceive these issues and how we (lay people) travel from superficial meanings to "understanding" even rudimentary concepts. Great work on your part, thank you.
I know the mechanisms of toxicity of nanotechnology/graphene, and I see them in so-called Covid and after these injections. And because nanotechnology has been widely used in tests, masks, filters, or "vaccines" (but it is also sprayed and added to water, drugs, food), so the conclusion is obvious.
'PlasmidGate' are you for this bioweapon technology? Or are you just sharing it with folks to show that them that these bioweapons are out there? These inventions are from the pit of hell.
Thank you for the extensive view. As the view from the top of the hill reveals there is a mountain of research being done. However well intentioned, there is a parallel universe of research (via DARPA, et al) on the destructive possibilities. Any attempt to replicate or create what God has done will ultimately result in disaster. The nano size along with the means of distribution (medical, water, air, food, etc.) make it impossible to substantially inhibit or stop its destruction of the human species (along with all other living things). Means of detox are limited and can easily be poisoned with nano-bots. Stopping this immoral activity should have happened 20 even 30 years ago. I think our efforts are likely too little, too late.
I there were ever planets with life like on earth, I get a feeling now why these planets are dead now. They simply destroyed it. They wanted to be God, but didn't understand what God means, says an agnostic.
This is diabolical shit
What an amazing (alarming) compilation of scientific articles! This is a whole new genre of concern…just when I thought the globalists had met quota >__<
Thank you for the heads up.
Thank you for this.
Yes, nanotechnology is what it's all about
And nanotechnology is all about genociding humanity... framed in the premise of medical advancements. NOT! Remember... they want 7 BILLION People dead by 2030. The deadly medical industry is full of s..t!!! Don't believe a word they say.
OMG!!!!! Who can even read this....pleeeeeeeezzzzeee...let me just be a human. Remember, that old thing that just had the 23 pairs of chromosomes...that highly flawed, yet mischievously ingenious old earth creature...I want myself back....pppllllleeeeeeezzzeee....gasp....gasp....
God help us all.
Confusing.
First, we cannot see anything smaller than fits in the optical microscope. All technologies with higher “resolution” are either snapshots of a very minuscule something or complete fiction based on “images” of dead something (following a protocol on how to prepare samples for electron microscopy) - again random and very minuscule.
The field of vision of these “images” is ridiculous. And it is not continuous: you cannot scroll the image left, right up or down. Most importantly, you cannot “see” the sample in its depth - because it has no depth, it is an ultra thin slice of dead something. It is dead - we cannot observe nano-scale things live.
None of these technologies are replicable. None of them leaves the “sample” intact for another observation. Since we cannot see what is happening there, the resulting “images” are pure fantasy ornamented with elaborate descriptions. None of these technologies can offer continuous observation of one particular sample over time long enough to draw any conclusions - cross-referenced to other observations of the same sample at a different point in time (like two days later).
Therefore, DNA, strands, or whatever they call it that is below the threshold of true observation (continuous, at different time points, under different stimuli, within large field of vision) is only inference at best and pure fantasy in general.
Second, how do you “control” structuring of something which you cannot see? How do you ensure that ALL presumed components fit nicely into a pattern of your imagination? What if some alleged “staples” go rogue and hide within the “good” structure? You won’t be able to detect it - because the sample intended for the detection / verification process would have to be destroyed.
Therefore, whatever is “produced” is completely unknown and unknowable. We do not have technical means to make true images of it, in all its sections and dimensions. We are unable to make a true inventory of a particular sample. And we cannot compare samples and check whether their contents (inventory) is identical or not across the whole “lot”.
Third, even if we had such technologies, how would you ensure 100% (with like million decimal places) repeatability of the “manufacturing” process when the material used is supposedly “live” (biological)?
Please. Give a link to a peer-reviewed paper that describes a true study of a live matter in any ultra-high res over an extended period of time, re-using the same sample, and resulting in real-time continuous movie of how the affected samples change. A “proof of life” of the said samples would be nice. One link will do, although - since science is based on replication of processes - more are needed to make it believable.
https://patents.justia.com/patent/11939574
https://patents.justia.com/patent/20200208343
https://patents.justia.com/patent/20190352640
DNA have been used for the rational design and construction of nanoscale Objects for nearly 30 years. Recently, ‘scaffolded DNA origami’ has emerged as one of the most promising assembly techniques in DNA nanotechnology with a broad range of applications (Rothemund, 2006, Nature, 440, 297-301). Since the creation of this method, software was developed to assist the process using computer-aided design (CAD) software allowing pre-calculating and determining the sequences of scaffolds and staples needed to form a certain shape.
Despite the big promise, DNA origami did not penetrate strongly to the industry. One of the main obstacles is the high price of the raw material, i.e., the single stranded DNA. While only small quantities are needed for regular laboratory experiments, when commercialization is considered, the cost is too high.
Although it is a well-known fact that RNA is much more abundant than DNA, RNA was not considered a potential “raw material” for production of origami structures. Endo et al., (Chem. Eur. J. 2014, 20, 15330-15333) and Wang et al., (Chem. Commun., 2013, 49, 5462-5464) describe preparation of nucleic acid origami using relatively short strands of artificially transcribed RNA with limited yield. Gerasimova and Kolpashchikov (Angew. Chem. Int. Ed. Engl. 2013 52(40) doi:10.1002anie.201303919 described an assay that analyzes bacterial RNA exploiting deoxyribozyme sensors—two DNA stands containing fragments complementary to a target analyte and fragments complementary to a fluorophore and quiencher-labeled fluorogenic reporter substrate. Gerasimova and Kolpashchikov showed that hybridization of the staples to the RNA unwinds its secondary structure to form “deoxyribozymes-on-a-string” complex. However, there is no example for real tools allowing mass-production of cheap and readily available origami nanostructures. There is an unmet need for methods utilizing a cheap source of genetic material that may be used for industrial scale manufacture of biological nanostructures.
SUMMARY OF THE INVENTION
Approximately 80 percent of the total RNA in rapidly growing mammalian cells (e.g., cultured HeLa cells) is a ribosomal RNA (rRNA) making it one of the most available and cheapest sources of genetic material. Until now, rRNA was not considered as a potential material for developing rationally designed biological structures. The present invention shows for the first time that rRNA may be used for manufacturing 2D and 3D rRNA origami nanostructures. Methods for processing rRNA and its folding to rRNA origami structures are provided as well.
In one aspect, the present invention provides an RNA origami nanostructure comprising one or more scaffold nucleic acid strands and a plurality of staple nucleic acid strands, wherein said one or more scaffold nucleic acid strand(s) comprises a ribosomal RNA (rRNA) nucleic acid strand, fragment or analog thereof.
https://patents.justia.com/patent/10420842
Since its introduction several years ago (Rothemund, 2006), scaffolded DNA origami has emerged as a powerful and elegant approach for bottom-up fabrication of complex shapes at the nanoscale. Shih, Douglas and others have extended DNA origami from 2D to 3D, and enhanced it with an open-source computer-aided design (CAD) tool, caDNAno (Dietz et al., 2009; Douglas et al., 2009a; Douglas et al., 2009b), enabling a remarkably diverse array of shapes that have been used for various applications, including imaging (Jungmann et al., 2012; Jungmann et al., 2010; Steinhauer et al., 2009), potential therapeutics (Douglas et al., 2012; Schuller et al., 2011), and metamaterials (Kuzyk et al., 2012; Bell et al., 2012; Schreibe et al., 2011).
WO 2012/061719 and Douglas et al. (2012), herein incorporated by reference as if fully described herein, disclose a DNA origami device useful in the targeted delivery of biologically active entities to specific cell populations.
In this invention, we describe an improved nucleic acid origami platform providing functional, stable, safe, non-immunogenic, and remote controllable therapeutic nano-devices. The platform also provide the means to provide a cargo in a ligand concentration dependent manner, control the activity of the devices by closing them at predetermined conditions, separately control multiple types of cargo, extend the shelf life of molecules such as drugs, vaccines, proteins, growth factors, cytokines, RNA molecules etc., and a tunable system to prevent drug tachyphylaxis by suppressing the endocytosis of drug-bound receptors from the cell surface. The platform is based on methods for modifying DNA origami devices by the addition of small molecule chemicals, peptides or large proteins, additional nucleic acid molecules,
inorganic quantum dots, nanocrystals or nanoparticles, liposomes, polysaccharides, polymers, carbon nanotubes, and additional materials.
The methods can also include enzymatic or non-enzymatic modification of the composition and structure of the DNA from which the device is made, such as methylation, acetylation, hydroxylation, fixation by chemical means, coating, etc. Finally, the platform can be achieved by designing the DNA origami device to be made of DNA that does not include certain motifs such as CpG, AT-rich regions etc.
Etc.
There is a rich scientific literature on the subject, which you can easily find
there is no way to get rid of these nanobots? is it possible that freemasonry and transhumanists do not have an antidote to use?
Or maybe they too are full of these nanobots, but they do not have the negative effects because those electromagnetic signals with deadly instructions are not sent to them?
My opinion on this is here:
https://outraged.substack.com/p/causes-of-injuries-and-deaths-from
The toxicity of graphene and other potentially toxic components used, such as heavy metals, is key to establishing a causal link to the adverse effects it can cause.
The mere presence of toxic graphene, and similar components, can cause amyloidosis.
Amyloidosis is also a common complication after Covid-19 injections, as also confirmed by Pfizer documents listing various types of amyloidosis as possible post-vaccination complications in a Postmarketing Experience document: https://phmpt.org/wp-content/uploads/2021/11/5.3.6-postmarketing-experience.pdf
So, the presence of toxic graphene can cause amyloidosis. However, the technology used in these injections is also based on peptides (as has been widely reported in the scientific literature: Self-assembling peptide semiconductors | https://www.science.org/doi/10.1126/science.aam9756), the production of amyloid in the bone marrow can lead to severe amyloidosis and related complications and death, including the currently manifested so-called sudden death syndrome.
Myeloperoxidase biodegrades graphene https://www.sciencedaily.com/releases/2018/08/180823113613.htm
“Myeloperoxidase is the first and so far only human enzyme known to break down carbon nanotubes, allaying a concern among clinicians that using nanotubes for targeted delivery of medicines would lead to an unhealthy buildup of nanotubes in tissues.”
https://onlinelibrary.wiley.com/doi/epdf/10.1002/anie.201806906
Medicinal Herbal Compounds With the MPO-Inhibiting Activity Showing Antioxidant, Anti-Inflammation, and Neuroprotective Effects (A GREAT LIST OF NATURAL ANTIOXIDANTS!) https://www.frontiersin.org/articles/10.3389/fphys.2020.00433/full
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6500609/pdf/NEUROSCIENCE2019-7547382.pdf Effect of N-Acetyl Cysteine on Intracerebroventricular Colchicine Induced Cognitive Deficits, Beta Amyloid Pathology, and Glial Cells
“It can be postulated that NAC might have reversed the effect of intraneuronal beta amyloid protein by acting on some downstream compensatory mechanisms which needs to be explored.”
https://nationaladdictionnews.com/2021/04/04/study-shows-how-the-nutritional-supplement-nac-can-help-prevent-strokes/ “The study by CHOP researchers suggests NAC may block the precipitation of amyloid plaque deposits, as well as help break up their formation, which could make a dramatic difference for those living with HCCAA.” “Amyloids cannot precipitate without aggregating, so if we can prevent that aggregation with a drug [NAC] that is already available, then we could make an incredible difference in the lives of these patients.”
"One of the most experienced free-radical researchers, the Japanese biochemist Yukie Niwa, estimates that at least 85% of chronic and degenerative diseases result from oxidative damage."
And yes, that's EXACTLY my conclusion!
Thus,
NAC, MSM (organic Sulphur), glycine are precursors of glutathione and does not allow aggregation of amyloid plaque formations (and they dissolve amyloid plaque formations)
They also prevent oxidative stress/oxidative damage
https://outraged.substack.com/p/nacs-protective-capacity-against
https://outraged.substack.com/p/nac-as-a-chelator-for-heavy-metals
https://outraged.substack.com/p/why-nac
In addition, you can use other antioxidants as well as some oxidants (such as CDS, for example).
it's crazy, I have all the symptoms of amyloidosis: even the tongue
One more thing - high temperature, UV light, blood acidity (opposite to alkaline), EMF are the elements that increase the formation of amyloid plaques. Therefore, first one needs to dissolve the amyloids, using NAC, etc., only then one can go to the sauna, stay in the sun, exercise intensively, etc.
Various cleansing methods, such as juicing, enemas, infra-red sauna, alkaline diet, etc. will be helpful, but the most important thing to start with is to dissolve these amyloid structures. Later, it is necessary through supplementation to maintain the right balance of oxidative stress to prevent oxidative damage (leading to blood clotting, amyloidosis, organ damage, death, etc.).
This will take time, as the biodistribution of this nanotechnology is into various organs, including bone marrow
https://www.docdroid.net/xq0Z8B0/pfizer-report-japanese-government-pdf
I already have some nac sachets at home, 600mg each.
On substack I also follow "managainstthemicrobes" and Dr. Ana Mihalcea. It seems that this amyloidosis also comes from a continuous accumulation of darpa hydrogel and polymers. For this reason, the intake of sodium citrate and methylene blue is suggested.
We'll see, thank you very much for your precious help. During covid I participated in numerous protests, I also individually took a megaphone that I had at home and went to the square to warn people of the risks of the covid vaccine, but very few people understood me. Then I received so many threats and I had to stop, I was afraid.
And this is a very dangerous condition. If I were you, I would immediately take 2-3000 mg of NAC daily, plus other antioxidants. You can monitor it with a d-dimer test, as I wrote;
In many pharmacies around the world, you can also buy ACC, the active ingredient of which is N-acetylcysteine (600mg), then I would take about 4 tablets a day (sometimes there is no time for online shipping)
https://pubs.rsc.org/en/content/articlelanding/2013/ra/c3ra40605a
one last thing: do you think that chlorella is another valid ally? in this link it seems that graphene oxide incorporates chlorella, but it is not clear if chlorella is then expelled from the body (with the go) or not, so I do not understand its effectiveness as a chelator. You can take a look and let me know, obviously when you have time?
amyloidosis would also explain why they find all those filaments that look like rubber inside the blood vessels of cadavers, but in reality they would be assembled proteins. They worked on multiple fronts at the same time, to destroy all of Humanity.
How much NAC do you think we should take? hoping to find a product that is not contaminated....
I tried CDS, that is, chlorine dioxide, but I had strange symptoms, that is, I was worse, my eyes were full of broken capillaries and very red, and sporadic chest pains. I stopped taking CDS, and I read everywhere that the latter reduces graphene oxide into reduced graphene oxide (rGO) which is even more inflammatory, and even more dangerous. Furthermore, if the situation presents a widespread and massive hyper inflammation, why use a product that oxidizes the tissues?
On the other hand, NAC being a precursor of glutathione, and therefore being an antioxidant, I would see it well as a possible ally (although there are unfortunately studies on the web that almost everything acts as a reducing agent for graphene oxide, be it melatonin, nac, vitamin c and more)
And yes, these rubbery structures are indeed amyloidosis, which is why products like NAC, cayenne pepper, etc. dissolve amyloidosis and prevent it from aggregating. Therefore, this is the key
Therefore, one of the tests that shows something is the d-dimer test
"Activation of fibrinolysis may lead to D‐dimer elevation, as the fibrinolytic pathway is known to be active in AL amyloidosis and could be the mechanism by which many patients have an increased bleeding risk."
thank you so much
Honestly, I have seen a huge number of people who improved after N-acetylcysteine and other antioxidants (MSM, glycine, quercetin and vit. C and zinc, resveratrol, Q10, etc.).
I use between 2-3000mg of NAC
Subjects were given 10 tablets (8000 mg of NAC) per day in distributed doses day:
https://outraged.substack.com/p/nac-replenishes-glutathione-in-hiv http://aliveandwellsf.org/articles/derosa_NAC_GSH_2000.pdf N-acetylcysteine replenishes glutathione in HIV infection
The clinical significance of this HIV-associated GSH deficiency is reflected by the strong association demonstrated recently between decreased survival in HIV disease and both low thiol levels in serum [42] and low GSB levels in CD4 T cells [46]. Clinical methods for replenishing GSH are well established [47]. N-acetylcysteine (NAC), a prodrug that supplies bioavailable cysteine necessary for the replenishment, is routinely administered to overcome pharmacologically induced GSH deficiency [5,6,48—51], for example due to acetaminophen or cyclophosphamide overdose. Thus, Droge [12,32,52], ourselves [45,53] and other studies [54—56] have suggested that NAC be evaluated as an effective means for preventing or reversing the GSH deficiency in HIV infection.
Drug dosage
NAC and placebo were supplied as indistinguishable effervescent tablets to be dissolved in water, juice or soda before ingestion.
Subjects were given 10 tablets (8000 mg of NAC) per day in distributed doses day.
NAC treatment is safe for HIV-infected subjects
We found no evidence of toxicity associated with NAC administration, either during the 8-week placebo controlled trial segment or the 6-month open-label segment.
NAC administration and survival
In previous studies, we have shown that low GSB levels are associated with decreased survival in an overall study group that included subjects from this trial.
Consistent with these findings, we find a significant association between NAC ingestion and improved 2—3 years survival in a Cox Proportional Hazards analysis comparing the survival (adjusted for baseline CD4 T-cell count and b2-microglobulin) of trial subjects who took NAC during the placebo-controlled and/or the open label segment of the trial with those who never took NAC.
Since NAC effectively replenishes GSH in HIV-infected people, it may also prove to be a useful therapeutic adjunct for replenishing GSH in other clinical situations.
GSH deficiency induced by alcohol and certain drugs
is well-known.
In addition, recent studies have implicated GSH deficiency in acute respiratory distress syndrome (ARDS) and septic shock [31,87—89], hepatitis [29], liver cirrhosis [18,90], hepatorenal failure [31], preeclampsia of pregnancy [91], cardiac failure [92], rheumatoid arthritis [93], neurodegenerative disorders [25,94], aging [27,95], pancreatitis [96], age-related macular degeneration [97] and diabetes [98,99].
Exploration of NAC therapy has already begun in some of these diseases [31].
I just read online that to form glutathione you need 3 amino acids: cysteine, glycine and glutamine. With only NAC, if the other two are missing, you only have a mucolytic.
I will take the other two as suggested, that is from hydrolyzed collagen peptides that are rich in glycine and glutamic acid which is then transformed into glutamine.
Also,
https://www.weforum.org/stories/2016/01/the-next-industry-revolution-will-not-be-televised/
If you’re still just talking about the fourth industrial revolution, you can stop theorising, because it’s here and making an impact that matters on business and society.
With the digital transformation of manufacturing well underway, the only thing needed to launch the next industrial revolution is wider access to exponential technologies — robotics, artificial intelligence (AI), sensors, 3D printing, nanotechnology, quantum computing. And now that these technologies are more affordable and their size more manageable, the fourth industrial revolution is up and running.
The World Economic Forum’s Annual Meeting at Davos this year is focused on this industrial revolution for good reason. Consider these statistics. The 4.9 billion items connected via the Internet of Things (IoT) in 2015 will reach 25 billion by 2020. Advanced manufacturing technologies are expected to double in value to $85 billion-plus globally by 2019. Venture capital investment in robotics and artificial intelligence (AI) has grown more than 70 percent per year since 2011.
But to the naked eye, it may be hard to discern this revolution.
https://www.weforum.org/stories/2012/05/small-is-beautiful-materials-by-design/ Ten years ago this all sounded like science fiction. But governments have since invested nearly US$ 70 billion in nanotechnology research, eager to be at the forefront of this revolution. This will be like the shift from horses to the internal combustion engine, or from vacuum tubes to silicon chips; a transformation enabling new industries to flourish.
Patents and literature don’t count, it’s all paper. Patents do not describe anything real.
I would like to see real-time continuous recording of the actual observation of nano-scale things. Most of all, how they change (combine, move, whatever) when manipulated by “us”.
Most most of all, how “we” know that they do what they are told to and when. Do they text us? Radio comms?
If that funny layered structure is made of, say, a trillion nano-units, how do we tell #xyz to do something while - at the same time - none of its brothers react to our command?
What about inertia? Time delay between the stimulus and reaction, in between their movements, and time delay from the stop command to the actual stop.
What about noise that can mess up communication (presuming there is some effective and accurate one)? Even the electromagnetic field of the body at this scale of miniaturization must be huge. What about interference between these tiny things? The domino effect when one fails to follow the command? Will its buddies throw it outside of the structure? How? Or will they allow its dead presence to slow down or distort the working of the whole structure?
What if 10% of these things go rogue? Will we ever know it? They do not have any transmitters. We cannot watch them in real time. Even if we managed to really “build” these structures, how do we track them and make real-time surveillance? 24/7, every tiny nanosecond - because this is the timeframe at which they operate.
How would you record all these data? Where? Could these data be meaningfully analyzed and interpreted at all? The moment you pull the record out to a printer, any nano-scale structure will already be miles away from its reporting point.
How many people would be needed to track all these data? It’s beyond our capacity. Add the human “I know better” attitude, and we are all in for a huge drama in the nano-lab.
How are these things protected from strong interferences? Induction fields? Solar radiation and its volatility? These two most obvious can affect our whole grid systems - so their impact on nano-helpless items must be catastrophic.
Aside from all these aspects... Where can we find true sequences of real-time images (like 24 fps) of these nano structures living and reacting? For one continuous minute, for the starters. To be serious, these images should have the size larger than the nano structure itself - so that we could see it in its environment.
If this imagery is not available - these scientists live in a fantasy world. They will surely produce more papers and patents to cover it up. Which does not make the absence of PROOF go away.
I am not saying these things do not exist - just asking for observable PROOF, not theories, not stories “about”.
Of course, talking about how this is to be used for drug delivery, so-called precision medicine is nonsense, and I've already written about it (less than 1% of the drug goes where it was supposed to go). On the other hand, it can certainly be used as a weapon, for biometrics, for geolocation and for CBDC (cryptography).
But above all, it is too toxic to use it.
https://outraged.substack.com/p/bombshell-studies
This is the research article by Bachelet:
https://web.archive.org/web/20211012193602/https://storage.googleapis.com/plos-corpus-prod/10.1371/journal.pone.0161227/1/pone.0161227.pdf?X-Goog-Algorithm=GOOG4-RSA-SHA256&X-Goog-Credential=wombat-sa%40plos-prod.iam.gserviceaccount.com%2F20211012%2Fauto%2Fstorage%2Fgoog4_request&X-Goog-Date=20211012T193558Z&X-Goog-Expires=86400&X-Goog-SignedHeaders=host&X-Goog-Signature=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
There's so much of it. They've really spent billions on this research. There are scientific papers, books, videos, labs, technologies. I mean, my Substack has so many links, and it's just a little drop from the ocean. 5G technology for IoT (Internet of Things), IoB (Bodies), and the Internet of Everything. New UV streetlamps, photonic equipment, biometric cameras, etc. Everything is connected and dedicated to these technologies. Yet how many patents and research are hidden, in the possession of the military, etc.?
https://youtu.be/h9LX4h79aHg - https://www.youtube.com/watch?v=h9LX4h79aHg&si=cu6BXQps3NKt0iB8
https://outraged.substack.com/p/hemorrhage-fever-or-ultrasonically
https://www.sec.gov/Archives/edgar/data/1403570/000149315221010243/form10-q.htm#V_009
Major Market Segments
Life Sciences. The life sciences industry was one of the early areas of adoption of QD technology, especially for QDs used in fluorescent markers in diagnostic applications. This includes both the in vitro use of QDs for marking (illuminating) particular cell types or metabolic processes for understanding diseases, and in vivo imaging made possible by QD fluorescence in near infrared that can be detected in deep tissues. The fluorescent qualities of QDs provide an attractive alternative to traditional organic dyes in bio-imaging. It is estimated that QDs are 20 times brighter and 100 times more stable than standard fluorescent indicators. QD technology is also being used in place of colloidal gold nanoparticles in lateral flow test kits such as those used in the rapid Covid 19 antigen test. QDs have been reported in literature to exponential improve the sensitivity of these test enabling earlier detection.
The Federal Drug Administration (“FDA”) has issued emergency use authorization (“EUA”) for medical tests that diagnose Covid-19. The FDA is responsible for protecting the public health by ensuring safety, efficacy, and security of all human and veterinary drugs, biological products, and medical devices. With regards to medical tests, the FDA usually does this by making manufacturers meet rigorous guidelines in an approval process that can take many months. During an emergency, such as a pandemic, it may not be possible to have all the evidence that the FDA would usually have before approving a medical test. If there’s evidence that strongly suggests that patients have benefited from a test, the agency can issue an EUA to make it available. One of the minimum requirements for granting EUA is that the known and potential benefits of the test outweigh the known potential risks. However, this is a minimum requirement and not the standard. The minimum standard can be met and EUA is still not given; there may be additional requirements, such as the test meeting reasonable thresholds for safety and effectiveness and/or people in urgent need of care based on a diagnosis. EUAs are only given during a declared emergency; outside of this, an EUA is never given.
Once the pandemic is over and should FDA EUA of Covid-19 tests be revoked. The 510K approval process which requires validation and submission of the test for FDA 510(k) clearance, which is one of the normally used medical device regulatory pathways for FDA approval would be required to continue to sell the test kits in the USA.
Quantum computers can track this data. This is certainly what CERN is all about. In the end, it is harmful. It will kill and maim, under the pretext of a new “quantum financial system” and “pandemics” or other health concerns.
I appreciate your extensive replies. It will take me some time to go through it all. I respect your work here a lot. In a sense, this all is like opening another frontier for science, and, obviously, it will require a major change in the way how we perceive these issues and how we (lay people) travel from superficial meanings to "understanding" even rudimentary concepts. Great work on your part, thank you.
This is a very good research paper on this subject:
https://particleandfibretoxicology.biomedcentral.com/articles/10.1186/s12989-016-0168-y Toxicity of graphene-family nanoparticles: a general review of the origins and mechanisms
Thank you kindly
I know the mechanisms of toxicity of nanotechnology/graphene, and I see them in so-called Covid and after these injections. And because nanotechnology has been widely used in tests, masks, filters, or "vaccines" (but it is also sprayed and added to water, drugs, food), so the conclusion is obvious.
No one is coming to save us .
I think so too, humanity should have rebelled in the times of covid
'PlasmidGate' are you for this bioweapon technology? Or are you just sharing it with folks to show that them that these bioweapons are out there? These inventions are from the pit of hell.
Thank you for the extensive view. As the view from the top of the hill reveals there is a mountain of research being done. However well intentioned, there is a parallel universe of research (via DARPA, et al) on the destructive possibilities. Any attempt to replicate or create what God has done will ultimately result in disaster. The nano size along with the means of distribution (medical, water, air, food, etc.) make it impossible to substantially inhibit or stop its destruction of the human species (along with all other living things). Means of detox are limited and can easily be poisoned with nano-bots. Stopping this immoral activity should have happened 20 even 30 years ago. I think our efforts are likely too little, too late.
I there were ever planets with life like on earth, I get a feeling now why these planets are dead now. They simply destroyed it. They wanted to be God, but didn't understand what God means, says an agnostic.
This all so unbelievable…